Teratogenic Effect of Trypan Blue on Rat Embryos cultivated in vitro
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چکیده
منابع مشابه
Trypan blue induced teratogenesis of rat embryos cultivated in vitro.
Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...
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L I T T L E information is available in the literature on the susceptibility of the hamster embryo to teratogens. Desoxycorticosterone acetate apparently has some teratogenic activity (Tedford & Risely, 1950), but the degree and type of abnormality produced by this agent in the hamster have not been recorded. Orsini (1952) has described naturally-occurring urogenital anomalies which appear in f...
متن کاملAccumulation of DNA, RNA, and protein by cultured rat embryos following maternal administration of a teratogenic dose of trypan blue.
The effect of trypan blue on the rates of DNA, RNA, and protein accumulation in rat embryos was investigated using a system of whole embryo culture. Embryos were isolated on the 10th gestational day (sperm day = Day 0) either 4 or 24 hr after maternal injection. The cultivation period was for 24 or 42 hr. The rate of DNA and RNA accumulation in the embryo following either a 4- or 24-hr previous...
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The teratogenicity of rabbit anti-rat visceral yolk-sac antiserum, injected into pregnant rats at either 8-5 or 9-5 days of gestation, has been confirmed. Normal rabbit serum was found not to be teratogenic. When conceptuses from 9-5-day pregnant rats were cultured for 48 h in heat-denatured homologous serum, to which antiserum was added for the final (or the penultimate) 6 h of culture, embryo...
متن کاملThe Effects of Trypan Blue on Chick Embryos
VARIOUS malformations in rats and mice have been observed to be caused by administration of the vital dye, Trypan blue (Gillman, Gilbert, Gillman, & Spence, 1948; Fox & Goss, 1956, 1957; Hamburgh, 1952, 1954; Waddington & Carter, 1952, 1953). Recently Waddington & Perry (1956) reported a teratogenic effect of Trypan blue on Amphibian embryos. The present paper deals with the effects of this dye...
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ژورنال
عنوان ژورنال: Nature
سال: 1965
ISSN: 0028-0836,1476-4687
DOI: 10.1038/206637a0